Micky Hoogendijk was born in Amsterdam in 1970. She and her mother Gine Hoogendijk lived there until Micky was eight. Her grandfather Dirk Albert Hoogendijk was a prominent art dealer. Hoogendijk grew up among artists, gallerists, theatre makers, actors and dancers. After moving to Overijssel province in the eastern Netherlands she spent a lot of time in the studio of her stepfather, painter Roelof Frankot. Hoogendijk graduated from an anthroposophic high school in Amsterdam and in the early 1990s became involved in the art scene as a result of her relationship with artist Rob Scholte. In her early twenties she became director of Rob Scholte BV and assisted him with his work on a monumental mural and ceiling painting entitled Après Nous le Deluge in Nagasaki, Japan. In 1994 their car was bombed in Amsterdam. Hoogendijk returned to the Dutch capital in 1997, where she established Micky Hoogendijk Productions and became creative director of Supperclub, a notorious artists’ society. From 2000 onwards she became famous in the Netherlands thanks to her role in the soap opera Goede Tijden, Slechte Tijden. 

In 2002 Hoogendijk left for Los Angeles to study method acting at the Eric Morris Actors Workshop. She appeared in Raising Helen with Kate Hudson, worked with Rutger Hauer and her face was used for a character in the computer game Killzone. In 2006 she founded a film company, Dramatic Beat, and developed a video site for young filmmakers. In 2008 she was nominated for the best actress in a feature film award for her role in Blindspot at the New York Independent Film & Video Festival. Hoogendijk appeared in several films and series in the Netherlands, and modelled for couturiers like Mart Visser. 

Hoogendijk continued working in film and television, both acting and presenting, until 2012, when the camera her mother Gine gave her just before her death in 2009 turned out to be a life-changing gift, and a guiding force in her life. She taught herself photography while living in San Francisco, Los Angeles and Austin, eventually coming to focus on non-commissioned portrait photography. Several of her pictures were exhibited for the first time in 2012 at Art Platform in Los Angeles. In the years that followed she exhibited on numerous occasions in the United States and the Netherlands, and also in Belgium, the UK, Turkey, Canada, Mexico, Colombia and Japan. Hoogendijk had her first solo exhibition, The Other Side of Fear Is Freedom, at Eduard Planting Gallery in Amsterdam in 2015. Her first museum retrospective, Through the Eyes of Others I See Me, was at Museum Jan van der Togt in Amstelveen in 2017. At the same time, Terra published a book of her work. Hoogendijk is represented by galleries in Amsterdam, London, Houston and Mexico City. 

After traveling to and living in many countries, Hoogendijk returned to the Netherlands in 2018, where she established her own studio and gallery in Hoogeloon, Noord-Brabant province. She exhibits her photographs and, since 2020, her bronze sculptures, in the Netherlands and abroad. The monograph STRENGTH vulnerability – Micky Hoogendijk, photography and sculpture by Karin van Lieverloo was published by Waanders Publishing in 2022. In spring 2023 Hoogendijk moved back to Amsterdam, where she now lives and works at Huize Zonnewijzer, a protected historic building in the Amsterdam School style which also houses The Ones at Home Gallery, a collaborative project between Hoogendijk and garden designer Erwin Stam. Hoogendijk is creating new work here, and shows it to visitors on request.